Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19041774.
- Also identified by DOI 10.1016/j.stem.2008.10.014.
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Abstract
Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in mouse and human. However, direct reprogramming in other species has not been reported. Here, we generated monkey iPS cells by retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC.
Medical subject headings
- Cell Differentiation
- Fibroblasts
- Macaca mulatta
- Pluripotent Stem Cells
- Transcription Factors
- Transduction, Genetic