New use of BCG for recombinant vaccines.
basic_science · Level V
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- Record sourced from PubMed, PMID 1904554.
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Abstract
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
Medical subject headings
- Antigens
- BCG Vaccine
- Genetic Vectors
- Mycobacterium bovis
- Vaccines, Synthetic