Regulating the motor for GLUT4 vesicle traffic.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19046566.
- Also identified by DOI 10.1016/j.cmet.2008.10.006.
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Abstract
Insulin-triggered trafficking of GLUT4 glucose transporter-loaded vesicles and their fusion with the plasma membrane are mechanical processes involving multiprotein complexes that coordinate and facilitate vesicle movement. Now, Yip et al. (2008) link myosin-1c to insulin signaling by demonstrating direct CaMKII-driven phosphorylation of this critical motor protein.
Medical subject headings
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Glucose Transporter Type 4
- Insulin
- Membrane Fusion
- Myosins
- Transport Vesicles