Mirror image DNA nanostructures for chiral supramolecular assemblies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19063615.
- Also identified by DOI 10.1021/nl803328v and PMC identifier 2669104.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
L-DNA, the mirror image of natural D-DNA, can be readily self-assembled into designer discrete or periodic nanostructures. The assembly products are characterized by polyacrylamide gel electrophoresis, circular dichroism spectrum, atomic force microscope, and fluorescence microscope. We found that the use of enantiomer DNA as building material leads to the formation of DNA supramolecules with opposite chirality. Therefore, the L-DNA self-assembly is a substantial complement to the structural DNA nanotechnology. Moreover, the L-DNA architectures feature superior nuclease resistance thus are appealing for in vivo medical applications.
Medical subject headings
- Crystallization
- DNA
- Nanostructures
- Nanotechnology