Challenges of designing trials for the primary prevention of stroke.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19064811.
- Also identified by DOI 10.1161/STROKEAHA.108.526947.
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Abstract
Prevention of a first stroke is an important strategy to reduce morbidity and mortality associated with cerebrovascular disease. In this discussion, we review challenges to development of clinical trials for prevention of a first stroke. Summary of Review- We discuss prevention of first stroke in the context of clinical trial design in the ARRIVE trial and a primary prevention trial in development for the elderly. Stroke is an important outcome in cerebrovascular disease trials in the elderly, but it may be trumped by coronary heart disease as a more common end point.
Medical subject headings
- National Institute of Neurological Disorders and Stroke (U.S.)
- Randomized Controlled Trials as Topic
- Stroke