Misoprostol does not alter the pharmacokinetics of propranolol.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 1906610.
- Also identified by PMC identifier 2398868.
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Abstract
Twelve healthy volunteers took part in a randomised, double-blind, balanced, cross-over study to investigate the effect of misoprostol on the pharmacokinetics of propranolol. The subjects took propranolol 80 mg twice daily by mouth plus either misoprostol 400 micrograms twice daily or placebo by mouth for 14.5 days, followed by a 2-week washout period, followed by the alternate treatment for 14.5 days. Misoprostol had no significant effect on the t/2, Cmax or AUC of propranolol either after a single dose or at steady state.
Medical subject headings
- Alprostadil
- Anti-Ulcer Agents
- Propranolol