Bcl-2 proteins and apoptosis: choose your partner.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19070569.
- Also identified by DOI 10.1016/j.cell.2008.11.029.
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Abstract
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
Medical subject headings
- Apoptosis
- Mitochondrial Membranes
- Proto-Oncogene Proteins c-bcl-2