Collateral damage from antigen receptor gene diversification.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19070571.
- Also identified by DOI 10.1016/j.cell.2008.11.024.
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Abstract
Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.
Medical subject headings
- Cytidine Deaminase
- DNA Breaks, Double-Stranded
- Receptors, Antigen