HMGA2, microRNAs, and stem cell aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19070572.
- Also identified by DOI 10.1016/j.cell.2008.11.026 and PMC identifier 3725266.
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Abstract
Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.
Medical subject headings
- Cellular Senescence
- HMGA2 Protein
- Mice
- MicroRNAs
- Stem Cells