Building a knowledge base for systems pathology.

Michael, Holger; Hogan, Jennifer; Kel, Alexander; Kel-Margoulis, Olga; Schacherer, Frank; Voss, Nico; Wingender, Edgar · Brief Bioinform · 2008

review · Level V

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Abstract

Translating the exponentially growing amount of omics data into knowledge usable for a personalized medicine approach poses a formidable challenge. In this article-taking diabetes as a use case-we present strategies for developing data repositories into computer-accessible knowledge sources that can be used for a systemic view on the molecular causes of diseases, thus laying the foundation for systems pathology.

Medical subject headings