The overexpression of major antioxidant enzymes does not extend the lifespan of mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19077044.
- Also identified by DOI 10.1111/j.1474-9726.2008.00449.x and PMC identifier 2667893.
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Abstract
We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
Medical subject headings
- Catalase
- Longevity
- Superoxide Dismutase