Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium.

Pfister, Anne; Zhang, Guoqing; Zareno, Jessica; Horwitz, Alan F; Fraser, Cassandra L · ACS Nano · 2008

basic_science · Level V

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Abstract

Difluoroboron dibenzoylmethane-polylactide, BF(2)dbmPLA, a biocompatible polymer-luminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature phosphorescence (RTP) are retained in aqueous suspension. The nanoparticles were internalized by cells and visualized by fluorescence microscopy. Luminescent boron biomaterials show potential for imaging and sensing.

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