A dissolution-diffusion model for the TAXUS drug-eluting stent with surface burst estimated from continuum percolation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19085944.
- Also identified by DOI 10.1002/jbm.b.31282.
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Abstract
A two-layer dissolution-diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading.
Medical subject headings
- Drug Delivery Systems
- Stents