Does loss of CD151 expression promote the metastasis of hypoxic colon cancer cells?
Level V
Where this comes from
- Record sourced from PubMed, PMID 19088010.
- Also identified by DOI 10.1158/1078-0432.CCR-08-2417.
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Abstract
Intratumoral hypoxia increases invasion and metastasis through multiple mechanisms, including changes in gene expression that are mediated by hypoxia-inducible factor 1. In hypoxic colon cancer cells, hypoxia-inducible factor 1 inhibits the expression of CD151, a cell surface molecule that normally tethers epithelial cells to the basement membrane, which may promote metastasis.
Medical subject headings
- Antigens, CD
- Cell Hypoxia
- Colonic Neoplasms