The new role of calcimimetics as vasculotropic agents.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19092812.
- Also identified by DOI 10.1038/ki.2008.563.
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Abstract
The discovery of the calcium-sensing receptor (CaSR) and the development of calcimimetics have provided new insights into calcium homeostasis and new therapeutic opportunities for parathyroid-related disorders. However, the CaSR is also implicated in various other cellular processes, and the translational applications of calcimimetics may not be exclusively calcium-centric. Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology.
Medical subject headings
- Calcinosis
- Calcium
- Cardiovascular Diseases