Sensing voltage across lipid membranes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19092925.
- Also identified by DOI 10.1038/nature07620 and PMC identifier 2629456.
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Abstract
The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1-S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing.
Medical subject headings
- Cell Membrane
- Ion Channel Gating
- Membrane Lipids
- Membrane Proteins