The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19101030.
- Also identified by DOI 10.1016/j.biomaterials.2008.11.031.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.
Medical subject headings
- Absorbable Implants
- Biocompatible Materials
- Bone and Bones
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Methylcellulose
- Ruthenium
- Tissue Engineering