Mitofusin 2 builds a bridge between ER and mitochondria.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19109886.
- Also identified by DOI 10.1016/j.cell.2008.12.005.
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Abstract
Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.
Medical subject headings
- Endoplasmic Reticulum
- GTP Phosphohydrolases
- Mitochondria