DNA Cytosine demethylation: are we getting close?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19109887.
- Also identified by DOI 10.1016/j.cell.2008.12.008.
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Abstract
Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.
Medical subject headings
- Cytosine
- DNA Methylation