Tracing the retrograde route in protein trafficking.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19109890.
- Also identified by DOI 10.1016/j.cell.2008.12.009.
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Abstract
Retrograde transport, in which proteins and lipids are shuttled between endosomes and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse range of cellular functions. Mechanistic studies that explore the molecular machinery involved in this retrograde trafficking route are shedding light on the functions of transport proteins and are providing fresh insights into possible new therapeutic directions.
Medical subject headings
- Protein Transport