Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19116271.
- Also identified by DOI 10.1073/pnas.0811914106 and PMC identifier 2629200.
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Abstract
Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated factor (TAF) complex. By generating altered holo-TFIID complexes in Drosophila we identify the ETO domain of TAF4 as a coactivator domain likely targeted by Pygopus, a protein that is required for Wingless-induced transcription of naked cuticle. These results establish a coactivator function of TAF4 and provide a strategy to dissect mechanisms of TFIID function in vivo.
Medical subject headings
- Drosophila Proteins
- Multiprotein Complexes
- Signal Transduction
- TATA-Binding Protein Associated Factors
- Transcription Factor TFIID
- Wnt Proteins