Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19117542.
- Also identified by DOI 10.1016/j.cmet.2008.12.010.
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Abstract
The first crystal structure of a full-length nuclear receptor complex on DNA reveals an interdomain contact between the ligand- and DNA-binding domains of subunits and illuminates the role of the 5' extension of the binding site in polarity of positioning. These findings have possible functional implications.
Medical subject headings
- PPAR gamma
- Retinoid X Receptor alpha