Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19125575.
- Also identified by DOI 10.1021/nl8025604.
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Abstract
A carbon nanotube transistor array was used to detect DNA hybridization. A new approach to ensure specific adsorption of DNA to the nanotubes was developed. The polymer poly (methylmethacrylate(0.6)-co-poly(ethyleneglycol)methacrylate(0.15)-co-N-succinimidyl methacrylate(0.25)) was synthesized and bonded noncovalently to the nanotube. Aminated single-strand DNA was then attached covalently to the polymer. After hybridization, statistically significant changes were observed in key transistor parameters. Hybridized DNA traps both electrons and holes, possibly caused by the charge-trapping nature of the base pairs.
Medical subject headings
- Biosensing Techniques
- DNA
- DNA Probes
- Nanotubes, Carbon