In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.
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- Record sourced from PubMed, PMID 19125672.
- Also identified by DOI 10.1086/596508.
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Abstract
The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.
Medical subject headings
- Antiprotozoal Agents
- Forkhead Transcription Factors
- Interleukin-10
- Leishmania guyanensis
- Leishmaniasis, Cutaneous
- Pentamidine