Remote optical switch for localized and selective control of gene interference.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19128006.
- Also identified by DOI 10.1021/nl802689k and PMC identifier 2776650.
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Abstract
Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.
Medical subject headings
- RNA Interference