Toward a genetics of cancer resistance.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19129501.
- Also identified by DOI 10.1073/pnas.0811616106 and PMC identifier 2630080.
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Abstract
Two of three humans never get cancer. Even the majority of heavy smokers remain cancer free. Is this a matter of chance, or are there cancer-resistant genotypes? Based on the evidence discussed, it would appear that evolution has favored a limited number of relatively common resistance genes that may nip incipient cancerous foci in the bud, i.e., to stop them at their inception. It is further suggested that resistance genes may act at the level of tissue organization in a dominant fashion.
Medical subject headings
- Neoplasms