The secret life of Smad4.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19135880.
- Also identified by DOI 10.1016/j.cell.2008.12.028.
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Abstract
Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
Medical subject headings
- Smad4 Protein