When sirtuins and NF-kappaB collide.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19135883.
- Also identified by DOI 10.1016/j.cell.2008.12.034.
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Abstract
Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.
Medical subject headings
- Aging
- Inflammation
- NF-kappa B
- Sirtuins