Effects of omeprazole on plasma levels of raltegravir.
Where this comes from
- Record sourced from PubMed, PMID 19143531.
- Also identified by DOI 10.1086/596503.
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Abstract
Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1-infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.
Medical subject headings
- Anti-HIV Agents
- Drug Interactions
- Omeprazole
- Plasma
- Pyrrolidinones