MicroRNA silencing in primates: towards development of novel therapeutics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19147547.
- Also identified by DOI 10.1158/0008-5472.CAN-08-2749.
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Abstract
MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic intervention. Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such compounds in the development of miRNA-based cancer therapeutics.
Medical subject headings
- MicroRNAs
- Neoplasms
- Primates