CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19151024.
- Also identified by DOI 10.1136/jnnp.2008.149336.
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Abstract
Collapsin response mediator protein 5 (CRMP5) antibodies are often associated with thymoma or small cell lung cancer and paraneoplastic syndromes such as limbic encephalitis (LE). A patient is described with myasthenia gravis who, following thymectomy and immunosuppression, acquired a viral infection and developed LE and increased levels of serum CRMP5 antibodies. The cognitive symptoms improved and CRMP5 antibody levels decreased after plasma exchange, suggesting that CRMP5 antibodies may have contributed to the development of LE.
Medical subject headings
- Antibodies
- Limbic Encephalitis
- Myasthenia Gravis
- Nerve Tissue Proteins