Role of polyethylene glycol integrity in specific receptor targeting of carbon nanotubes to cancer cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19152309.
- Also identified by DOI 10.1021/nl8033174.
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Abstract
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.
Medical subject headings
- Carrier Proteins
- ErbB Receptors
- Nanotubes, Carbon
- Neoplasms
- Polyethylene Glycols
- Receptors, Cell Surface