Small RNAs in transcriptional gene silencing and genome defence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19158787.
- Also identified by DOI 10.1038/nature07756 and PMC identifier 3246369.
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Abstract
Small RNA molecules of about 20-30 nucleotides have emerged as powerful regulators of gene expression and genome stability. Studies in fission yeast and multicellular organisms suggest that effector complexes, directed by small RNAs, target nascent chromatin-bound non-coding RNAs and recruit chromatin-modifying complexes. Interactions between small RNAs and nascent non-coding transcripts thus reveal a new mechanism for targeting chromatin-modifying complexes to specific chromosome regions and suggest possibilities for how the resultant chromatin states may be inherited during the process of chromosome duplication.
Medical subject headings
- Gene Silencing
- Genome
- Transcription, Genetic