Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro.
basic_science · Level V
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- Record sourced from PubMed, PMID 1916504.
- Also identified by PMC identifier 1379035.
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Abstract
The action of epidermal growth factor on the human duodenal mucosa has been studied by estimating the crypt cell production rate in cultured explants, using a stathmokinetic technique with crypt microdissection. The addition of epidermal growth factor (400 ng/ml) to paired explants from five patients caused an almost fivefold increase in the crypt cell production rate, showing that epidermal growth factor has a trophic action on the human duodenal mucosa in vitro.
Medical subject headings
- Epidermal Growth Factor
- Intestinal Mucosa