Old nuclei spring new leaks.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 19167324.
- Also identified by DOI 10.1016/j.cell.2009.01.004.
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Abstract
The nuclear pore complex (NPC) regulates the bidirectional movement of cell components across the nuclear envelope. In this issue, D'Angelo et al. (2009) demonstrate that the NPC loses essential protein subunits as cells age, resulting in increased nuclear permeability and potentially contributing to organismal aging.
Medical subject headings
- Aging
- Cell Nucleus
- Nuclear Pore