MicroRNAs: target recognition and regulatory functions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19167326.
- Also identified by DOI 10.1016/j.cell.2009.01.002 and PMC identifier 3794896.
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Abstract
MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Medical subject headings
- Gene Expression Regulation
- MicroRNAs