Collapsing glomerulopathy: beyond serendipity in mouse genetics.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 19180149.
- Also identified by DOI 10.1038/ki.2008.554 and PMC identifier 2787237.
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Abstract
Clinical correlates suggest that collapsing glomerulopathy results from the pathogenic interaction between patients' intractable genetic susceptibilities and environmental insults. When the environmental insults include a virus that introduces its own pathogenic genes, the interactions become more complex. Chan et al. combine reverse and forward genetic techniques in mice toward understanding this complexity with HIV and identify candidate genetic modifiers of collapsing glomerulopathy.
Medical subject headings
- Genetic Predisposition to Disease
- Glomerulonephritis