PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19180231.
- Also identified by DOI 10.1371/journal.pone.0004316 and PMC identifier 2628736.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BACKGROUND: Previous studies have demonstrated that knockout or inhibition of Platelet/Endothelial Cell Adhesion Molecule (PECAM, CD31) in a number of murine strains results in impaired inflammatory responses, but that no such phenotype is seen in the C57BL/6 (B6) murine background. METHODOLOGY/PRINCIPAL FINDINGS: We have undertaken a quantitative trait locus (QTL) mapping effort between FVB/n (FVB) and B6 mice deficient for PECAM to identify the gene or genes responsible for this unique feature of B6 mice. We have identified a locus on murine chromosome 2 at approximately 35.8 Mb that is strongly associated (LOD score = 9.0) with inflammatory responses in the absence of PECAM. CONCLUSIONS/SIGNIFICANCE: These data potentiate further study of the diapedesis machinery, as well as potential identification of new components of this machinery. As such, this study is an important step to better understanding the processes of inflammation.
Medical subject headings
- Inflammation
- Peritonitis
- Platelet Endothelial Cell Adhesion Molecule-1