Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19181860.
- Also identified by DOI 10.1073/pnas.0812945106 and PMC identifier 2633215.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers.
Medical subject headings
- Breast Neoplasms
- Gene Expression Profiling
- Gene Rearrangement
- Genome, Human