Clinical utility of array comparative genomic hybridization: uncovering tumor susceptibility in individuals with developmental delay.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 19187739.
- Also identified by DOI 10.1016/j.jpeds.2008.07.045 and PMC identifier 4072200.
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Abstract
Microarray-based comparative genomic hybridization can determine genome-wide copy number alterations at the kilobase level. We highlight the clinical utility of microarray-based comparative genomic hybridization in determining tumor susceptibility in 3 patients with dysmorphic features and developmental delay, likely decreasing both morbidity and mortality in these patients.
Medical subject headings
- Comparative Genomic Hybridization
- Developmental Disabilities
- Genetic Predisposition to Disease
- Li-Fraumeni Syndrome
- Peutz-Jeghers Syndrome