Why we should put clothes on mice.
Level V
Where this comes from
- Record sourced from PubMed, PMID 19187768.
- Also identified by DOI 10.1016/j.cmet.2009.01.004.
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Abstract
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
Medical subject headings
- Energy Metabolism
- Ion Channels
- Mitochondrial Proteins
- Thermogenesis