Maintaining reduced viral fitness and CD4 response in HIV-infected patients with viremia receiving a boosted protease inhibitor.

Grant, Philip; Taylor, Jonathan; Cain, Pat; Short, William; Gallant, Joel; Farthing, Charles; Thal, Gary; Coakley, Eoin et al. · Clin Infect Dis · 2009

rct · Level II

Where this comes from

Abstract

When fully suppressive regimens are not available, incompletely suppressive regimens also provide immunologic benefits. In this study, with stable background therapy, human immunodeficiency virus (HIV)-infected patients who were randomized to receive atazanavir or boosted atazanavir, compared with those who continued boosted protease inhibitor therapy, maintained similar virologic and immunologic control, resistance-mutation patterns, and replication capacities with reduced use of lipid-lowering medication.

Medical subject headings