Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19193857.
- Also identified by DOI 10.1073/pnas.0810682106 and PMC identifier 2650169.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Transduction of the primate cortex with adeno-associated virus (AAV)-based gene therapy vectors has been challenging, because of the large size of the cortex. We report that a single infusion of AAV2 vector into thalamus results in widespread expression of transgene in the cortex through transduction of widely dispersed thalamocortical projections. This finding has important implications for the treatment of certain genetic and neurodegenerative diseases.
Medical subject headings
- Cerebral Cortex
- Dependovirus
- Genetic Therapy
- Neurodegenerative Diseases