Biomimetic nanowire coatings for next generation adhesive drug delivery systems.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19199759.
- Also identified by DOI 10.1021/nl803219f and PMC identifier 2824765.
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Abstract
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.While some chemically modified, microstructured surfaces have been studied in aqueous environments,adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.
Medical subject headings
- Biomimetic Materials
- Drug Carriers
- Drug Delivery Systems
- Nanowires