Elongator bridges tubulin acetylation and neuronal migration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19203572.
- Also identified by DOI 10.1016/j.cell.2009.01.024.
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Abstract
Neuronal cell migration and maturation are crucial for the development of the mammalian cerebral cortex. In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin.
Medical subject headings
- Histone Acetyltransferases
- Neurogenesis
- Neurons
- Tubulin