An amino acid shuffle activates mTORC1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19203575.
- Also identified by DOI 10.1016/j.cell.2009.01.021.
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Abstract
The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
Medical subject headings
- Glutamine
- Protein Kinases