Bottom-up engineering of peptide cell translocators based on environmentally modulated quadrupole switches.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19206548.
- Also identified by DOI 10.1021/nn700239j.
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Abstract
Designing water-soluble peptides that camouflage their polarity to cross an anhydrous phase may significantly impact drug delivery. We engineered neutrally charged peptides endowed with a conformational switch that enables them to solubilize in both water and lipid. These peptides are capable of translocating without resorting to active internalization mechanisms. Lipid solubility is induced by a quadrupolar arrangement. Our passive translocation motif possesses the highest efficiency and is derived from cellular prions.
Medical subject headings
- Drug Carriers
- Drug Design
- Models, Molecular
- Peptides