Do benefits of earlier antiretroviral treatment initiation outweigh harms for individuals at risk for poor adherence?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19210173.
- Also identified by DOI 10.1086/596768 and PMC identifier 3032571.
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Abstract
Clinicians may defer antiretroviral treatment for patients with suboptimal adherence. We used a validated computer simulation of HIV disease progression to compare alternative treatment thresholds for patients with suboptimal adherence. Earlier treatment increased life expectancy across a wide adherence range (50%-100% of doses taken). Delaying treatment for patients with suboptimal adherence may not always be appropriate.
Medical subject headings
- Antiviral Agents
- HIV Infections