Palindromic gene amplification--an evolutionarily conserved role for DNA inverted repeats in the genome.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 19212324.
- Also identified by DOI 10.1038/nrc2591.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The clinical importance of gene amplification in the diagnosis and treatment of cancer has been widely recognized, as it is often evident in advanced stages of diseases. However, our knowledge of the underlying mechanisms is still limited. Gene amplification is an essential process in several organisms including the ciliate Tetrahymena thermophila, in which the initiating mechanism has been well characterized. Lessons from such simple eukaryotes may provide useful information regarding how gene amplification occurs in tumour cells.
Medical subject headings
- Gene Amplification
- Genome
- Inverted Repeat Sequences
- Neoplasms