Engineering parathyroid cells to treat secondary hyperparathyroidism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 19219003.
- Also identified by DOI 10.1038/ki.2008.635.
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Abstract
Kanai et al. used antisense technology to reduce excessive PTH production. The authors have overcome technical difficulties to demonstrate that, by strategies of RNA interference, a steady reduction of PTH secretion can be induced in cultured parathyroid-cell spheroids and in athymic nude mice with hyperplastic parathyroid cells transplanted from patients with secondary hyperparathyroidism.
Medical subject headings
- Cell Transplantation
- Hyperparathyroidism, Secondary
- Parathyroid Glands